Agonist Beta


Beta agonists or beta adrenergic agonists are a group of drugs used to relieve or control the symptoms of narrowing of the airways caused by asthma or chronic obstructive pulmonary disease. This group of drugs is a type of bronchodilator drug .

Beta agonists work by activating beta-2 cell receptors, so that the muscles in the respiratory tract are more relaxed. That way, the previously narrowed respiratory tract will be wider, the flow of air in and out of the lungs will be smoother, and complaints, such as wheezing or difficulty breathing, can subside.

According to how it works, beta agonists are divided into 3 types, namely fast acting ( short acting beta agonist / SABA), slow acting ( long acting beta agonist / LABA), and very slow acting ( ultra long acting beta agonist / ultra LABA).

Fast-acting beta agonists can be used to treat asthma attacks or sudden narrowing of the airways. While slow acting beta agonists are used to prevent or reduce the frequency of recurrence of asthma or COPD .

Precautions Before Using Beta Agonists

Follow the doctor's recommendations and advice while undergoing treatment with beta agonists. Before using this drug, you need to pay attention to the following points:

  • Tell your doctor about any allergies you have. Beta agonists should not be used by patients who are allergic to this drug.
  • Tell your doctor if you have or have had  diabetes , high blood pressure, epilepsy , heart disease, hyperthyroidism , liver disease, glaucoma , or hypokalemia .
  • Carry out the control according to the schedule given by the doctor. You will need to have your blood sugar and blood pressure checked regularly while taking beta agonists.
  • Tell your doctor if you are taking certain medications, supplements, or herbal products.
  • Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.
  • See your doctor right away if you have an allergic drug reaction, serious side effect, or overdose after using a beta agonist.

Beta Agonist Side Effects and Dangers

The side effects of beta agonists can vary depending on the type of drug. However, in general, there are some side effects that can occur after using drugs that are included in beta agonists, namely:

  • Cough
  • Headache , dizziness, or migraine
  • Sore throat
  • Nausea or vomiting
  • Feeling nervous or restless
  • Heart palpitations or fast heart rate

The use of certain types of beta agonists can also increase the risk of respiratory tract infections. Check with your doctor if the side effects mentioned above appear. You should also see a doctor immediately if you have  an allergic drug reaction or more serious side effects, such as:

  • Extreme dizziness to the point of fainting
  • Narrowing of the airways (bronchospasm) that comes on suddenly and gets worse
  • Chest pain , fast, irregular heartbeat, or palpitations
  • Cramps or muscle weakness

Some types of beta agonists can also increase the risk of hypokalemia, which is low levels of potassium in the blood.

Types, Trademarks and Dosage of Beta Agonists

The following are the types of drugs that are included in the beta agonist class, along with their trademarks and dosages:

1. Short-Acting Beta-Agonist (SABA)

Short acting beta agonists (SABAs) are a type of beta-agonist that works quickly, so they can be used to treat attacks of narrowing of the respiratory tract due to asthma or COPD that occur suddenly.

This drug can work immediately within minutes and the effect lasts for 4-6 hours. Some examples of drugs that belong to the SABA class are:

Salbutamol

Drug form: Inhaler

Merek dagang: Astharol, Azmacon, Fartolin, Glisend, Salbuven, Suprasma, Velutine

Terbutaline

Drug forms: Tablets, caplets, syrups, inhalers, respules , and injections

Trademarks: Astherin, Bricasma, Forasma, Lasmalin, Molasma, Nairet, Neosma

2. Long-Acting Beta-Agonist (LABA)

Long acting beta agonist (LABA) is a type of beta agonist whose drug effects can last as long as 12 hours. This medicine can be used 1-2 times a day.

Some examples of drugs that fall into the LABA class are:

Formoterol

Drug form: Inhaler and nebulizer solution

Trademarks: Innovair, Symbicort, Genuair Duaklir

Olodaterol

Drug form: Inhaler

Trademarks: Infortispir Respimat, Spiolto Respimat, Striverdi Respimat

Salmeterol

Drug form: Inhaler

Trademarks: Flutias, Respitide, Salmeflo, Seretide Diskus

Procaterol

Drug form: Inhaler, tablet and syrup

Trademarks: Asterol, Ataroc, Meptin, Sesma

Vilanterol

Drug form: Inhaler

Trademark: -

Vilanterol is available in combination with fluticasone. The dosage of this preparation to control symptoms of COPD or asthma is 1 inhale which is equivalent to 25 mcg/100 mcg (vilanterol/fluticasone) once daily.

3. Ultra Long-Acting Beta-Agonist (Ultra LABA)

Ultra long-acting beta-agonist (Ultra LABA) is a beta agonist whose therapeutic effect can last for 24 hours. This medication is generally used once a day. Examples of Ultra PROFIT are:

Indacaterol

Drug form: Inhaler

Trademarks: Onbrez Breezhaler, Ultibro Breezhaler

Labels: Drug

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