Adenosine is a drug used to assist the process of cardiac radiology examinations in patients who are unable to carry out normal activities. This drug will usually be used with thallium-201.

In addition, this drug is also sometimes used in the treatment of certain heart rhythm disorders, such as supraventricular tachycardia.

Adenosine has a strong cardiac vasodilator (widening blood vessel) effect, resulting in smoother blood flow. In addition, adenosine also affects the electrical activity in the heart, so it can help restore regular heart rhythm.

Adenosine trademarks: Bio ATP, Lapibion, Neuro ATP, Vitap, Pro ATP

What is Adenosine

The groupPrescription drugs
BenefitAs an adjunct drug in cardiac radiology examination
Consumed byAdults and children
Adenosine for pregnant and lactating womenCategory C:  Animal studies have shown adverse effects on the fetus, but there are no controlled studies in pregnant women.

Drugs should only be used if the expected benefit outweighs the risk to the fetus.

Adenosine is not known to be absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without consulting your doctor first.

Drug formInject

Precautions Before Using Adenosine

The following are some things you should pay attention to before using adenosine:

  • Tell your doctor about any allergies you have. Adenosine should not be used by patients who are allergic to this drug.
  • Tell your doctor if you have or have had asthma , sick sinus syndrome , QT prolongation syndrome, or AV block. Adenosine should not be given to patients with these conditions.
  • Tell your doctor if you have or have ever had heart disease , hypotension, heart attack , slow heart rate ( bradycardia ), chronic obstructive pulmonary disease ( COPD ), seizures, or anginal chest pain .
  • Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.
  • Tell your doctor if you are taking certain medications, supplements or herbal products,
  • See your doctor right away if you experience a drug allergic reaction , overdose, or serious side effect after using adenosine.

Adenosine Dosage and Usage

Adenosine will be injected into a vein (intravenous / IV) directly or through an IV. The injection will be carried out directly by a doctor or medical officer under the supervision of a doctor at the hospital. In general, the following adenosine dosages are based on their intended use:

Purpose: Helping the process of myocardial imaging

  • Adult: 140 mcg/kg/minute for 6 minutes, given by infusion. The maximum dose is 0.84 mg/kgBW.

Goal: Treatment of supraventricular tachycardia

  • Adult: Initial dose of 3 mg injected rapidly, over 2 seconds into a large peripheral or central vein. If needed, an additional dose of 6 mg can be given after 1-2 minutes, then followed by an additional dose of 12 mg, 2 times, after 1-2 minutes.
  • Children weighing less than 50 kg: The initial dose is 50–100 mcg/kgBW, then the dose may be increased by 50–100 mcg/kgBW after 1–2 minutes, until the heart rhythm is regular. The maximum dose is 300 mcg/kg body weight.

How to Use Adenosine Correctly

Adenosine injection will be given directly in the hospital by a  doctor or medical personnel under the supervision of a doctor through injection into a vein (intravenous / IV). Follow the doctor's advice and directions before, during, and after the injection.

During the adenosine injection, the doctor will monitor the patient's blood pressure, heart rate, respiratory function, and heart rhythm.

nteraksi Adenosine with Other Drugs

The following are some of the side effects that may occur if adenosine is used with other medicines:

  • Enhanced effect of adenosine when used with dipyridamole
  • Decreased effect of adenosine when used with aminophylline or theophylline
  • Increased risk of developing dangerous heart rhythm disturbances, such as heart block when used with carbamazepine
  • Increased risk of developing ventricular fibrillation when used with digoxin

Adenosine Side Effects and Dangers

Some of the side effects that can occur after adenosine injections are:

  • Face, chest, or neck, feeling warm and red ( flushing )
  • Shortness of breath or shortness of breath
  • Nauseous
  • Dizziness or headache
  • Aches or pain in the neck or jaw

Report to your doctor if the side effects mentioned above do not subside or get worse. Report and see a doctor immediately if you experience an allergic drug reaction or serious side effects, such as:

  • Chest pain that doesn't get better
  • Shortness of breath is getting worse
  • Heart beat
  • Severe dizziness that makes you feel like passing out
  • Seizure
  • Severe headache or blurry vision
  • Weakness or numbness that occurs suddenly

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